منابع مشابه
L-arginine "paradox" in coronary atherosclerosis.
To the Editor: Miner et al1 in a recent work used the steady-state N2arginine to examine the transorgan L-arginine gradients in the peripheral and coronary circulation. They found that during acetylcholine infusion a significant gradient was detected, indicating that the stimulation of NOS induces arginine transport. A body of evidence suggests that L-arginine supplementation improves endotheli...
متن کاملTranslational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox.
L-Arginine is the only endogenous nitrogen-containing substrate of NO synthase (NOS), and it thus governs the production of NO during nervous system development as well as in disease states such as stroke, multiple sclerosis, Parkinson's disease, and HIV dementia. The "arginine paradox" refers to the dependence of cellular NO production on exogenous L-arginine concentration despite the theoreti...
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Reduced production of nitric oxide (NO) is one of the first indications of endothelial dysfunction and precedes overt cardiovascular disease. Increased expression of Arginase has been proposed as a mechanism to account for diminished NO production. Arginases consume l-arginine, the substrate for endothelial nitric oxide synthase (eNOS), and l-arginine depletion is thought to competitively reduc...
متن کاملTo give or not to give? Lessons from the arginine paradox.
Arginine is one of the 20 amino acids (AA) found in proteins and synthesized by human cells. However, arginine is also the substrate for a series of reactions leading to the synthesis of other AA and is an obligatory substrate for two enzymes with diverging actions, arginases and nitric oxide synthases (NOS), giving origin to urea and NO, respectively. NO is a very potent vasodilator when produ...
متن کاملThe prevention paradox or the inequality paradox?
In February this year, a new edition of Geoffrey Rose’s classical book Strategy of Preventive Medicine was published, with a commentary by Kay-Tee Khaw and Michael Marmot. The commentary summarizes the life and work of Geoffrey Rose, explains the main content and impact of the classical book and gives plenty of examples that illustrate the validity of Rose’s theses. Coincidentally, in the Febru...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2002
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.119.7